Journal: Pharmaceuticals

Article Title: Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes

doi: 10.3390/ph15060668

Figure Lengend Snippet: Organ biodistribution and intraoperative NIR FLI; ( A ) “Ex vivo” NIR FLI 6 h after 500 µM injection of RR11 and 23 ( MSA14 ) was performed to assess the compound accumulation in tumors and organs. ( B ) Representative intraoperative near-infrared (NIR), color and pseudo-colored fluorescent signal merge images of one 23 ( MSA14 ) injected subcutaneously engrafted OVCAR-3 mouse in vivo and ex vivo.

Article Snippet: A second intraoperative compatible imaging system (FLARE ® , Curadel LLC, Nattick, MA, USA) was used to assess the clinical utility of 23 ( MSA14 ).

Techniques: Ex Vivo, Injection, In Vivo

Journal: Pharmaceuticals

Article Title: Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes

doi: 10.3390/ph15060668

Figure Lengend Snippet: Biodistribution of RR11 and 23 ( MSA14 ) in SKOV-3 s.c. models. RR11 ( A ) and 23 ( MSA14 ) ( B ) were intravenously injected into n = 2 and n = 4 mice, respectively, and imaged at 2, 6, and 24 h with a dose of 500 and 100 µM. The fluorescence signal in the tumors (*), liver (#), limb (†), spine (‡) and background in the flank muscle (yellow square), is presented in one representative mouse. All animals were euthanized when indicated and “ex vivo” NIR FLI was performed. ( C ) 23 (MSA14) injected SKOV-3 mice were additionally imaged with the intraoperative imaging system “in vivo” and “ex vivo”. NIR exposure times are indicated in brackets.

Article Snippet: A second intraoperative compatible imaging system (FLARE ® , Curadel LLC, Nattick, MA, USA) was used to assess the clinical utility of 23 ( MSA14 ).

Techniques: Injection, Fluorescence, Ex Vivo, Imaging, In Vivo